Signal line 'A' is 0.005 mil. An adjacent dynamic signal line 'B' should maintain a "two-signal-width" distance from signal line 'A'. So that from the center of line 'A' to the center of line 'B', there should be 0.0025 + 0.005 + 0.005 + 0.0025 = 0.015mil.
Target bias should maintain "one-signal-width" spacing from the signal.